Dr Subrata Bose-- My Research(Medical Imaging & Bioinformatics) & Publication

My Research

My research is focused on developing methodologies for the quantitative use of multi-modality medical images to examine the dynamic changes in selected functional processes and to investigate the effectiveness of new therapies in vivo (Drug Discovery). I'm also interested in developing computational and statistical models/methods for processing and analysing clinical data (Bioinformatics & Neuroinformatics), Computerised System Validation and Audit including ICH GCP and 21 CFR part 11.

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My Talks

■"PET Data Analysis" for St. George's University of London Post Graduate Students Hammersmith Hospital Campus(19th March 2008), UK.

■ "Pattern Recognition and membrane protein prediction problem" On International Workshop on Advances in Pattern Recognition(IWAPR), (22nd July 2007), Plymouth, UK. Download

■ "Researchers Use of Academic Libraries and their Services" - Organised jointly by the Research Information Network and Consortium of Research Libaries in the British Isles at the Institute of Physics, 76 Portland Place, London - (30th April 2007). Download

■ "Membrane Protein Prediction" on 12th International Conference on Intelligent Systems for Molecular Biology (ISMB) and 3rd European Conference on Computational Biology (ECCB)-(31st July 2004).

■ "Use of Neural Networks to Predict and Analyze Membrane Proteins in the Proteome" in London Metropolitan University, London, UK (11th March 2004).

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Research Funding

■ Currently received £8000 Emerald pre-commercialisation fund (from London Development Agency) for making a prototype of a Bioinformatics platform for membrane protein prediction (generated from my PhD research) (2008)

■ Medical Research Council(MRC) CSC Core research funding (£25000) for PET Methodology Research(2006-2011)

■ The recipient of research funding (£27000) for making membrane protein prediction platform from London Metroplotian University (2003-2006) _______________________________________________________

Reviewer

■ Reviewer, Oxford Bioinformatics Journal (Oxford University Press), UK (from 15/09/2005 to current date)

■ Reviewer , Briefings in Bioinformatics (Oxford University Press), UK (from 26/10/2007 to current date)

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Research Publication

Bose S.K., Turkheimer F.E., Howes O.H., Mehta M.A., Cunliffe R., Stokes,P., Grasby P.M., (2008). The application of an artificial neural network to classification of schizophrenic patients and healthy controls using [18F] Fluorodopa PET imaging, Schizophrenia Research, (In Press).

Selvaraj S., Murthy V.N. , Bhagwagar Z. , Bose S.K., Hinz R., Grasby P.M., Cowen P.J.(2008)Diminished 5-HTT binding in brain stem may be a state marker of major depression: A positron emission tomography study with [11C]DASB, Submitted to Biological Psychiatry.

Brownsett S., Bose S.K., Turkhiemer F.E. & Wise R.J.,(2008) The functional connectivity of speech comprehension and production. (In Preparation)

Selvaraj S., Murthy V.N. , Bhagwagar Z. , Bose S.K., Cowen P.J.& Grasby P.M.(2008) Lower brain serotonin transporter binding potential in unipolar acutely depressed patients – A preliminary [11C] DASB PET study. (In Preparation)

Sharp D.J., Turkhiemer F.E., Bose S.K. & Wise R.J.(2008) control of language after brain injury: changing fronto-parietal interactions after aphasic stroke. (In Preparation)

Ahmed I., Hammers A., Bose S.K. , Turkheimer F.E, Hotton G., Quinn N. and Brooks D.J.(2008) Glutamate neurotransmission in Parkinson’s disease dyskinesias : A C11 CNS 5161 PET study. (In Preparation)

Bose S. K.,Browne A., Kazemian H., White K., (2008). Classifying Membrane Proteins in the Proteome by Using Artificial Neural Networks Based on the Preferential Parameters of Amino Acids In by J. Tenreiro (Editor),B. Patkai (Eds.) & I.J. Rudas Intelligent Engineering Systems and Computational Cybernetics, Springer, 2008(In Press)

Bose S. K., Kazemian H., Browne A., White K., (2007). Use of Artificial Neural Networks and Effects of Amino Acid Encodings in Membrane Protein Prediction Problem In by S. Singh (Editor), & M. Singh (Eds.) Progress in Pattern Recognition, Springer, London. ISBN: 978-1-84628-944-6

Bose S.K., Kazemian H., Browne A., White K., (26th - 28th June 2006). Presenting a novel neural network architecture for membrane protein prediction. 10th IEEE International Conference on Intelligent Engineering Systems (INES 2006), ISBN:1-4244-9708-8 and ISBN of CD:1-4244-9709-6, London Metropolitan University, UK.

Bose, S., Kazemian, H., White, K. & Browne., A. (2005). Use Of Neural Networks To Predict And Analyse Membrane Proteins In The Proteome. BMC Bioinformatics. ISSN 1471-2105.

Bose, S., Kazemian ,H. ,White ,K & Browne., A. (2005). Use Of Neural Networks To Predict And Analyse Membrane Proteins In The Proteome. Proceedings of the Bioinformatics and Systems Biology Conference, Edinburgh, UK, 18.

Bose ,S., Browne, A., Kazemian, H. & White, K. (2004). Applying Perl to data set creation for biological data mining. Poster at 12th International Conference on Intelligent Systems for Molecular Biology (ISMB) and 3rd European Conference on Computational Biology, Glasgow, UK.

Bose ,S., Browne, A., Kazemian, H. & White, K. (2004). Predicting membrane spanning regions with neural networks. Poster at Young Bioinformaticians' Forum at Royal Society of Chemistry Molecular Modeling Group, Oxford, UK.

Bose ,S., Browne, A., Kazemian, H. & White, K. (2004). Neural networks for membrane protein detection. Royal Society of Chemistry Symposium on Chemical Technologies in Pharmaceutical Industry, London, UK

Bose, S. and Browne, A. (2003). Knowledge Discovery in Bioinformatics using Neural Networks. Proceedings 6th International Conference On Computer And Information Technology, Dhaka, Bangladesh (ISBN: 984-584-005-1)

A. Sarker, S. Pradhan, I. Mukhopadhyay, S.Bose, S. Roy & M. Chatterjee(1999). Genetic basis of inhibitory effect of an ethanolic extract of trianthema portulacastrum L. in carbon tetrachloride-induced mouse liver damage. Cell Biology International, Academic Press, vol. 23, no. 10, pp. 703-708(6)

Abstract presented in Conferences

Sharp D.J., Brownsett S., Bose S.K., Turkhiemer F.E. & Wise R.J.,(2007) The functional connectivity of speech comprehension and production, SFN, San Diego, USA

Bose S.K., Turkheimer F.E., Howes O., Mehta M.A. , Cunliffe R., Stokes P.R. & Grasby P.M.(2008) A Neural Predictor of Schizophrenia Based on Striatal [18F] Fluorodopa Uptake Measured with PET, HBM, Melbourne, Australia

Selvaraj S., Murthy V.N. , Bhagwagar Z. , Bose S.K., Cowen P.J. & Grasby P.M.(2008) Lower serotonin transporter binding potential in unipolar depressed patients: a preliminary [11C] DASB PET study, SOBP, Washington, DC, USA

Sharp D.J., Turkhiemer F.E., Bose S.K. & Wise R.J.(2007) control of language after brain injury: changing fronto-parietal interactions after aphasic stroke, ABN conference, London, UK.

Bose, S.,A. Banerjee & M. Chatterjee: Nickel promotes Rat Hepatocarcinogenesis in VIIth West Bengal State Department of Science & Technology Congress held at B.E. College, West Bengal, India

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Everything that is really great and inspiring is created by the individual who can labor in freedom.
Albert Einstein, 'Out of My Later Years,' 1950